|
KMID : 1134820070360080960
|
|
Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 8 p.960 ~ p.964
|
|
|
Single-Dose Oral Toxicity in Rat and Bacterial Reverse Mutation Assay of Psoralea corylifolia L. Extracts
|
|
Kim Sun-A
Lim Sun-Hye
Ahn Ji-Yun
Kim Sung-Ran
Ha Tae-Youl
|
|
|
Abstract
|
|
|
|
This study was performed to examine the toxicity of Psoralea corylifolia L. by the single?dose oral tests in rat and bacterial reverse mutation assay. In single?dose oral toxicity tests, 5 mL ethanol extract of This study was performed to examine the toxicity of Psoralea corylifolia L. by the single?dose oral toxicity tests in rat and bacterial reverse mutation assay. In single?dose oral toxicity tests, 5 mL ethanol extract of P. corylifolia L. were directly injected into 10 rats (5 males and 5 females) at a dosage of 2 g/㎏. Death practice was not detected during breeding periods (14 days), and LD?? was calculated over 2 g/㎏. No difference were observed with control group in the growth rate and histological observations. In bacterial reverse mutation assay, his(?) Salmonella Typhimurium TA98, TA100, TA1535, TA1537 and trp(?) Escherichia coli WP2uvrA (pKM101) were used for assessing the toxicity of ethanol extracts of P. corylifolia L.. No significant difference in formation of the colonies and no dose?dependent increase was observed regardless of the addition of S9 mix. The results showed that ethanol extracts of P. corylifolia L. did not have single?dose oral toxicity and mutagenic toxicity.
|
|
|
KEYWORD
|
|
|
Psoralea corylifolia L., single-dose oral toxicity, bacterial reverse mutation assay, Salmonella Typhimurium
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|